eht 1864 Search Results


eht 1864 2hcl  (TargetMol)
N/A
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eht1864  (Tocris)
95
Tocris eht1864
Rac1 inhibition reduces bFGF-induced and PDGFbb-induced aSMCs proliferation. (A) Representative images of airway smooth muscle cell (aSMC) proliferation from control and severe asthmatics induced by bFGF and PDGFbb, in the absence and in the presence of the Rac1 inhibitor, <t>EHT1864.</t> Nuclei are detected by 4′,6-diamidino-2-phenylindole staining (blue) and aSMC proliferation by EdU staining (green). Scale bar, 25 µm. (B, C) Quantification of aSMC proliferation by EdU staining in the absence (B) and in the presence (C) of EHT1864. The results are expressed as the percentage of cell proliferation (EdU-positive cells) (mean±SEM of n=3 independent experiments). Kruskal-Wallis test followed by Dunns’ post-test were used. *P<0.05, **p<0.01 versus untreated cells from control subjects; $ P<0.05 versus untreated cells from patients with severe asthma; # p<0.05 versus cells from control subjects.
Eht1864, supplied by Tocris, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/eht+1864/pmc07982925-62-10-14?v=Tocris
Average 95 stars, based on 1 article reviews
eht1864 - by Bioz Stars, 2026-08
95/100 stars
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eht1864  (Santa Cruz Biotechnology)
92
Santa Cruz Biotechnology eht1864
Rac1 inhibition reduces bFGF-induced and PDGFbb-induced aSMCs proliferation. (A) Representative images of airway smooth muscle cell (aSMC) proliferation from control and severe asthmatics induced by bFGF and PDGFbb, in the absence and in the presence of the Rac1 inhibitor, <t>EHT1864.</t> Nuclei are detected by 4′,6-diamidino-2-phenylindole staining (blue) and aSMC proliferation by EdU staining (green). Scale bar, 25 µm. (B, C) Quantification of aSMC proliferation by EdU staining in the absence (B) and in the presence (C) of EHT1864. The results are expressed as the percentage of cell proliferation (EdU-positive cells) (mean±SEM of n=3 independent experiments). Kruskal-Wallis test followed by Dunns’ post-test were used. *P<0.05, **p<0.01 versus untreated cells from control subjects; $ P<0.05 versus untreated cells from patients with severe asthma; # p<0.05 versus cells from control subjects.
Eht1864, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/eht+1864/pmc04402142-489-19-20?v=Santa+Cruz+Biotechnology
Average 92 stars, based on 1 article reviews
eht1864 - by Bioz Stars, 2026-08
92/100 stars
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eht 1864  (Selleck Chemicals)
93
Selleck Chemicals eht 1864
Rac1 inhibition reduces bFGF-induced and PDGFbb-induced aSMCs proliferation. (A) Representative images of airway smooth muscle cell (aSMC) proliferation from control and severe asthmatics induced by bFGF and PDGFbb, in the absence and in the presence of the Rac1 inhibitor, <t>EHT1864.</t> Nuclei are detected by 4′,6-diamidino-2-phenylindole staining (blue) and aSMC proliferation by EdU staining (green). Scale bar, 25 µm. (B, C) Quantification of aSMC proliferation by EdU staining in the absence (B) and in the presence (C) of EHT1864. The results are expressed as the percentage of cell proliferation (EdU-positive cells) (mean±SEM of n=3 independent experiments). Kruskal-Wallis test followed by Dunns’ post-test were used. *P<0.05, **p<0.01 versus untreated cells from control subjects; $ P<0.05 versus untreated cells from patients with severe asthma; # p<0.05 versus cells from control subjects.
Eht 1864, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/eht+1864/pmc12395885-319-20-23?v=Selleck+Chemicals
Average 93 stars, based on 1 article reviews
eht 1864 - by Bioz Stars, 2026-08
93/100 stars
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eht 1864  (ExonHit Therapeutics SA)
90
ExonHit Therapeutics SA eht 1864
Rac1 inhibition reduces bFGF-induced and PDGFbb-induced aSMCs proliferation. (A) Representative images of airway smooth muscle cell (aSMC) proliferation from control and severe asthmatics induced by bFGF and PDGFbb, in the absence and in the presence of the Rac1 inhibitor, <t>EHT1864.</t> Nuclei are detected by 4′,6-diamidino-2-phenylindole staining (blue) and aSMC proliferation by EdU staining (green). Scale bar, 25 µm. (B, C) Quantification of aSMC proliferation by EdU staining in the absence (B) and in the presence (C) of EHT1864. The results are expressed as the percentage of cell proliferation (EdU-positive cells) (mean±SEM of n=3 independent experiments). Kruskal-Wallis test followed by Dunns’ post-test were used. *P<0.05, **p<0.01 versus untreated cells from control subjects; $ P<0.05 versus untreated cells from patients with severe asthma; # p<0.05 versus cells from control subjects.
Eht 1864, supplied by ExonHit Therapeutics SA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/eht+1864/pmc02994602-518-10-6?v=ExonHit+Therapeutics+SA
Average 90 stars, based on 1 article reviews
eht 1864 - by Bioz Stars, 2026-08
90/100 stars
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eht-1864 cay17258  (Funakoshi ltd)
90
Funakoshi ltd eht-1864 cay17258
Rac1 inhibition reduces bFGF-induced and PDGFbb-induced aSMCs proliferation. (A) Representative images of airway smooth muscle cell (aSMC) proliferation from control and severe asthmatics induced by bFGF and PDGFbb, in the absence and in the presence of the Rac1 inhibitor, <t>EHT1864.</t> Nuclei are detected by 4′,6-diamidino-2-phenylindole staining (blue) and aSMC proliferation by EdU staining (green). Scale bar, 25 µm. (B, C) Quantification of aSMC proliferation by EdU staining in the absence (B) and in the presence (C) of EHT1864. The results are expressed as the percentage of cell proliferation (EdU-positive cells) (mean±SEM of n=3 independent experiments). Kruskal-Wallis test followed by Dunns’ post-test were used. *P<0.05, **p<0.01 versus untreated cells from control subjects; $ P<0.05 versus untreated cells from patients with severe asthma; # p<0.05 versus cells from control subjects.
Eht 1864 Cay17258, supplied by Funakoshi ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/eht+1864/pm33310911-231-0-5?v=Funakoshi+ltd
Average 90 stars, based on 1 article reviews
eht-1864 cay17258 - by Bioz Stars, 2026-08
90/100 stars
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eht 1864  (Aladdin Scientific Corporation)
92
Aladdin Scientific Corporation eht 1864
Rac1 inhibition reduces bFGF-induced and PDGFbb-induced aSMCs proliferation. (A) Representative images of airway smooth muscle cell (aSMC) proliferation from control and severe asthmatics induced by bFGF and PDGFbb, in the absence and in the presence of the Rac1 inhibitor, <t>EHT1864.</t> Nuclei are detected by 4′,6-diamidino-2-phenylindole staining (blue) and aSMC proliferation by EdU staining (green). Scale bar, 25 µm. (B, C) Quantification of aSMC proliferation by EdU staining in the absence (B) and in the presence (C) of EHT1864. The results are expressed as the percentage of cell proliferation (EdU-positive cells) (mean±SEM of n=3 independent experiments). Kruskal-Wallis test followed by Dunns’ post-test were used. *P<0.05, **p<0.01 versus untreated cells from control subjects; $ P<0.05 versus untreated cells from patients with severe asthma; # p<0.05 versus cells from control subjects.
Eht 1864, supplied by Aladdin Scientific Corporation, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/eht+1864/pm38663542-50-49-62?v=Aladdin+Scientific+Corporation
Average 92 stars, based on 1 article reviews
eht 1864 - by Bioz Stars, 2026-08
92/100 stars
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eht 1864 2hcl  (Aladdin Scientific Corporation)
N/A
InformationEHT 1864 2HCl EHT 1864 2HCl is a potent Rac family GTPase inhibitor with K d of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.In vitroEHT 1864
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eht 1864  (Cayman Chemical)
N/A
EHT 1864
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eht 1864  (BOC Sciences)
N/A
EHT 1864 is a potent Rac family GTPase inhibitor with Kd of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.
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eht 1864  (Toronto Research Chemicals)
N/A
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Image Search Results


Rac1 inhibition reduces bFGF-induced and PDGFbb-induced aSMCs proliferation. (A) Representative images of airway smooth muscle cell (aSMC) proliferation from control and severe asthmatics induced by bFGF and PDGFbb, in the absence and in the presence of the Rac1 inhibitor, EHT1864. Nuclei are detected by 4′,6-diamidino-2-phenylindole staining (blue) and aSMC proliferation by EdU staining (green). Scale bar, 25 µm. (B, C) Quantification of aSMC proliferation by EdU staining in the absence (B) and in the presence (C) of EHT1864. The results are expressed as the percentage of cell proliferation (EdU-positive cells) (mean±SEM of n=3 independent experiments). Kruskal-Wallis test followed by Dunns’ post-test were used. *P<0.05, **p<0.01 versus untreated cells from control subjects; $ P<0.05 versus untreated cells from patients with severe asthma; # p<0.05 versus cells from control subjects.

Journal: Thorax

Article Title: Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling

doi: 10.1136/thoraxjnl-2020-216271

Figure Lengend Snippet: Rac1 inhibition reduces bFGF-induced and PDGFbb-induced aSMCs proliferation. (A) Representative images of airway smooth muscle cell (aSMC) proliferation from control and severe asthmatics induced by bFGF and PDGFbb, in the absence and in the presence of the Rac1 inhibitor, EHT1864. Nuclei are detected by 4′,6-diamidino-2-phenylindole staining (blue) and aSMC proliferation by EdU staining (green). Scale bar, 25 µm. (B, C) Quantification of aSMC proliferation by EdU staining in the absence (B) and in the presence (C) of EHT1864. The results are expressed as the percentage of cell proliferation (EdU-positive cells) (mean±SEM of n=3 independent experiments). Kruskal-Wallis test followed by Dunns’ post-test were used. *P<0.05, **p<0.01 versus untreated cells from control subjects; $ P<0.05 versus untreated cells from patients with severe asthma; # p<0.05 versus cells from control subjects.

Article Snippet: When indicated, human aSMCs were treated with the Rac inhibitor, EHT1864 (10 −5 M; Tocris Bioscience), P21-activated kinases (Pak) inhibitor IPA3 (10 −5 M; Tocris Bioscience), Akt inhibitor VIII (10 −5 M; Calbiochem), MEK inhibitor PD98059 (10 −5 M; ThermoFisher), JAK inhibitor ruxolitinib (10 −5 M; InvivoGen) added 30 min before stimulation with bFGF (25 ng/mL; Miltenyi Biotech), PDGF-bb (25 ng/mL; Miltenyi Biotech), interleukins (IL)-13 (10 ng/mL; Miltenyi Biotech), IL-33 (10 ng/mL; Miltenyi Biotech), IL-17 (20 ng/mL; Miltenyi Biotech), IL-9 (10 ng/mL; Miltenyi Biotech) or TSLP (10 ng/mL; Miltenyi Biotech) for 48 hours.

Techniques: Inhibition, Control, Staining

Role of Rac1/P21-activated kinases (Pak1) in bFGF-induced activation of Akt-dependent signalling pathway. (A) Immunoblot analysis and corresponding quantification of Pak and STAT3 expression and phosphorylation in control airway smooth muscle cell (aSMCs) stimulated with bFGF or PDGFbb at different time points, in the absence, or in the presence of EHT1864 (n=4–5 independent experiments). (B) Control aSMC proliferation induced by bFGF and PDGFbb, in the absence and in the presence of inhibitors of PAK (IPA3), Akt (Akt Inhib VIII), P44/42 (PD98059) or JaAK2 (ruxolitinib). Nuclei are detected by 4′,6-diamidino-2-phenylindole staining (blue) and haSMC proliferation by EdU staining (green). Scale bar, 25 µm. Quantification of aSMC proliferation by EdU staining. The results are expressed as the percentage of EdU-positive cells. (n=3–4 independent experiments). Data are presented as mean±SEM. Kruskal-Wallis test followed by Dunns’ post-test were used. *P<0.05, **p<0.01, ***p<0.001 versus untreated cells; $$ p<0.01, $$$ p<0.001 versus bFGF treated cells; ## p<0.01, ### p<0.001 versus PDGFbb treated cells.

Journal: Thorax

Article Title: Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling

doi: 10.1136/thoraxjnl-2020-216271

Figure Lengend Snippet: Role of Rac1/P21-activated kinases (Pak1) in bFGF-induced activation of Akt-dependent signalling pathway. (A) Immunoblot analysis and corresponding quantification of Pak and STAT3 expression and phosphorylation in control airway smooth muscle cell (aSMCs) stimulated with bFGF or PDGFbb at different time points, in the absence, or in the presence of EHT1864 (n=4–5 independent experiments). (B) Control aSMC proliferation induced by bFGF and PDGFbb, in the absence and in the presence of inhibitors of PAK (IPA3), Akt (Akt Inhib VIII), P44/42 (PD98059) or JaAK2 (ruxolitinib). Nuclei are detected by 4′,6-diamidino-2-phenylindole staining (blue) and haSMC proliferation by EdU staining (green). Scale bar, 25 µm. Quantification of aSMC proliferation by EdU staining. The results are expressed as the percentage of EdU-positive cells. (n=3–4 independent experiments). Data are presented as mean±SEM. Kruskal-Wallis test followed by Dunns’ post-test were used. *P<0.05, **p<0.01, ***p<0.001 versus untreated cells; $$ p<0.01, $$$ p<0.001 versus bFGF treated cells; ## p<0.01, ### p<0.001 versus PDGFbb treated cells.

Article Snippet: When indicated, human aSMCs were treated with the Rac inhibitor, EHT1864 (10 −5 M; Tocris Bioscience), P21-activated kinases (Pak) inhibitor IPA3 (10 −5 M; Tocris Bioscience), Akt inhibitor VIII (10 −5 M; Calbiochem), MEK inhibitor PD98059 (10 −5 M; ThermoFisher), JAK inhibitor ruxolitinib (10 −5 M; InvivoGen) added 30 min before stimulation with bFGF (25 ng/mL; Miltenyi Biotech), PDGF-bb (25 ng/mL; Miltenyi Biotech), interleukins (IL)-13 (10 ng/mL; Miltenyi Biotech), IL-33 (10 ng/mL; Miltenyi Biotech), IL-17 (20 ng/mL; Miltenyi Biotech), IL-9 (10 ng/mL; Miltenyi Biotech) or TSLP (10 ng/mL; Miltenyi Biotech) for 48 hours.

Techniques: Activation Assay, Western Blot, Expressing, Phospho-proteomics, Control, Inhibition, Staining